CLINICAL TRIALS AND OBSERVATIONS Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group
نویسندگان
چکیده
Francesco Lo-Coco,1,2 Giuseppe Avvisati,3 Marco Vignetti,4 Massimo Breccia,4 Eugenio Gallo,5 Alessandro Rambaldi,6 Francesca Paoloni,7 Giuseppe Fioritoni,8 Felicetto Ferrara,9 Giorgina Specchia,10 Giuseppe Cimino,4 Daniela Diverio,4 Erika Borlenghi,11 Giovanni Martinelli,12 Francesco Di Raimondo,13 Eros Di Bona,14 Paola Fazi,7 Antonio Peta,15 Alberto Bosi,16 Angelo M. Carella,17 Francesco Fabbiano,18 Enrico M. Pogliani,19 Maria C. Petti,20 Sergio Amadori,1 and Franco Mandelli,7 for the Italian GIMEMA Cooperative Group
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710
Arsenic trioxide (As2O3) is a highly effective treatment for patients with relapsed acute promyelocytic leukemia (APL); its role as consolidation treatment for patients in first remission has not been defined. We randomized 481 patients (age > 15 years) with untreated APL to either a standard induction regimen of tretinoin, cytarabine, and daunorubicin, followed by 2 courses of consolidation th...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Induction therapy with idarubicin alone significantly influences event-free survival duration in patients with newly diagnosed hypergranular acute promyelocytic leukemia: final results of the GIMEMA randomized study LAP 0389 with 7 years of minimal follow-up
Giuseppe Avvisati, Maria Concetta Petti, Francesco Lo-Coco, Maria Luce Vegna, Sergio Amadori, Michele Baccarani, Nicola Cantore, Eros Di Bona, Felicetto Ferrara, Giuseppe Fioritoni, Eugenio Gallo, Rosangela Invernizzi, Mario Lazzarino, Vincenzo Liso, Guglielmo Mariani, Francesco Ricciuti, Carmine Selleri, Simona Sica, Dino Veneri, and Franco Mandelli, for the Italian Cooperative Group GIMEMA (G...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Therapy of Molecular Relapse in Acute Promyelocytic Leukemia
Fourteen patients with PML/RARa-positive acute promyelocytic leukemia (APL) were given salvage therapy at the time of first molecular relapse. All patients had achieved first molecular remission after the AIDA protocol (all-trans retinoic acid [ATRA] 1 idarubicin) and were being prospectively monitored by reverse transcriptase-polymerase chain reaction (RT-PCR). Molecular relapse was defined as...
متن کاملCLINICAL TRIALS AND OBSERVATIONS AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance
Giuseppe Avvisati,1 Francesco Lo-Coco,2,3 Francesca Paola Paoloni,4 Maria Concetta Petti,5 Daniela Diverio,6 Marco Vignetti,6 Roberto Latagliata,6 Giorgina Specchia,7 Michele Baccarani,8 Eros Di Bona,9 Giuseppe Fioritoni,10 Filippo Marmont,11 Alessandro Rambaldi,12 Francesco Di Raimondo,13 Maria Grazia Kropp,14 Giovanni Pizzolo,15 Enrico M. Pogliani,16 Giuseppe Rossi,17 Nicola Cantore,18 France...
متن کاملMaintenance therapy with all-trans retinoic acid and arsenic trioxide improves relapse-free survival in adults with low- to intermediate-risk acute promyelocytic leukemia who have achieved complete remission after consolidation therapy
BACKGROUND Currently, the optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who have achieved complete remission (CR) after completing consolidation chemotherapy remains controversial. The comparative effectiveness of the all-trans retinoic acid (ATRA) plus arsenic trioxide (As2O3) maintenance strategy with classic ATRA plus chemotherapy has not been evaluated. In...
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